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Psychedelic drugs a new erainpsychiatry? PMC Their work was directed toward development of potential radioligands for in vivo PET imaging of 5-HT2A receptors that would be selective over 5-HT2C receptors. One compound was discovered that had approximately 100-fold selectivity for both affinity and function at the 5-HT2A versus 5-HT2C receptor. Their high affinity and relative selectivity for the 5-HT2A receptor has made some of these compounds useful as agonist ligands for in vivo PET imaging (Ettrup et al., 2010; Finnema et al., 2014). Neither 4 nor 8 days of chronic treatment with MDL11939 had any significant effect on 5-HT2A density or function. Mice showed tolerance to the behavioral effects of DOI that began 24 hours after the first dose of DOI and persisted to the end of the experiment. The significant reduction in HTR responses was consistent with the decreased density of cortical 5-HT2A receptors. After chronic treatment with Psychedelics MDL11939, however, a challenge dose...